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KMID : 0986520090090030155
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Korean Journal of Endoscrine Surgery
2009 Volume.9 No. 3 p.155 ~ p.160
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The Relationship between the p27 Expression of Papillary Thyroid Cancer Cells Obtained by FNA and Cervical Lymph Node Metastasis
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Lee Kwan-Ju
Lee Jung-Uee
Kim Jeong-Soo
Kim Tai-Gyu
Lee Sang-Chul
Kim Jeong-Gu
Ahn Chang-Joon
Kim Say-June
Lee Dong-Ho
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Abstract
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Purpose: The p27 gene as a tumor suppressor gene is associated with colorectal cancer, gastric cancer and breast cancer. Some studies have shown a relationship between the underexpression of p27 and lymph node metastasis in papillary thyroid carcinoma. The aim of this study is to evaluate the relationship between a p27 expression of the papillary thyroid cancer cells obtained by fine needle aspiration (FNA) and cervical lymph node metastasis.
Methods: This study included 60 patients with papillary thyroid cancer and who underwent total thyroidectomy or lobectomy. Central lymph node dissection was routinely done. Out of these patients, 30 patients underwent a FNA procedure during the operation. Immunohistochemical staining for p27 antibody was performed on the papillary thyroid cancer tissues and cells.
Results: Cervical lymph node metastasis is correlated with the tumor size and lymphovascular invasion (P＜0.001). The underexpression of p27 for the papillary thyroid cancer tissues and cells was associated with lymph node metastasis (P=0.009).
Conclusion: An evaluation of the p27 expression for the papillary thyroid cancer cells obtained by FNA may be useful as a predictor for lymph node metastasis before surgery.
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KEYWORD
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Papillary thyroid cancer, Fine needle aspiration, p27, Lymph node metastasis
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